Physical Fitness and Hot Executive Function in Alzheimer's Risk
National Taiwan Normal University
240 participants
Jan 10, 2025
OBSERVATIONAL
Conditions
Summary
This 18-month study tracks how physical fitness relates to executive function in older adults, aiming to determine if fitness improvements predict better cognitive performance. Participants complete assessments at baseline and 18 months, including cardiorespiratory fitness (YMCA bike test), muscle strength (chest and leg press tests), and executive function (computer tasks with brain activity recording via EEG). Additional measures include physical activity questionnaires, cognitive screening (MMSE), memory tests (digit span), demographics (age, sex, education), and blood tests for APOE ε4 gene status. No exercise program will be provided, allowing observation of natural fitness-cognition relationships in daily life.
Eligibility
Inclusion Criteria3
- Age 50-70.
- Able to engage in fitness testing.
- Normal vision or corrected-to-normal vision.
Exclusion Criteria7
- Suffering from cardiopulmonary-related diseases.
- Suffering from cognitive, neurological or psychiatric disorders (e.g., dementia, Parkinson's disease, epilepsy, depression, schizophrenia, etc.).
- Suffering from infectious diseases (e.g., hepatitis, human immunodeficiency virus or Creutzfeldt-Jakob disease).
- Having a history of drug or alcohol abuse.
- Having colour vision deficiency (e.g., colour blindness).
- Having a family history of aneurysm.
- Taking medications that affect brain function.
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Interventions
No interventions will be conducted during the observation period, maintaining participants' normal daily living conditions.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07081269