RecruitingPhase 2NCT07082738

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

A Multicentre, Parallel-group, Phase IIb, Randomised, Double-blind, Placebo-controlled, 4-Arm, 24-Week Study to Evaluate the Efficacy and Safety of AZD6793 Tablets in Adult Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (PRESTO)

Sponsor

AstraZeneca

Enrollment

1,160 participants

Start Date

Jun 27, 2025

Study Type

INTERVENTIONAL

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Summary

This Phase IIb dose-ranging study will evaluate the efficacy and safety of 3 different doses of AZD6793 compared with placebo tablets in participants with moderate to very severe chronic obstructive pulmonary disease.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called AZD6793 in people with moderate to very severe COPD (chronic obstructive pulmonary disease) — a lung disease that makes it progressively harder to breathe — to see if it can reduce flare-ups (called exacerbations) and improve lung function. **You may be eligible if...** - You are 40 or older with a confirmed COPD diagnosis for at least 12 months - You have had at least 2 moderate flare-ups or 1 severe flare-up in the past year - You are a current or past smoker with at least 10 pack-years of smoking history - You have been on stable COPD maintenance therapy for at least 3 months - You are stable (no flare-up) for at least 4 weeks before starting **You may NOT be eligible if...** - You have asthma, pulmonary fibrosis, lung cancer, or other significant lung diseases besides COPD - You have serious cardiovascular disease, including a recent heart attack or uncontrolled heart rhythm problems - You have a history of inflammatory bowel disease (Crohn's or ulcerative colitis) - You have HIV, active liver disease, or a cancer history within the past 5 years Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAZD6793

Oral dosage

OTHERPlacebo

Oral dosage

Locations(363)

Research Site

Birmingham, Alabama, United States

Research Site

Glendale, Arizona, United States

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Phoenix, Arizona, United States

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Phoenix, Arizona, United States

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Phoenix, Arizona, United States

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Canoga Park, California, United States

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La Mesa, California, United States

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Los Angeles, California, United States

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Newport Beach, California, United States

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Norco, California, United States

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Tustin, California, United States

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Lakewood, Colorado, United States

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Brandon, Florida, United States

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Cape Coral, Florida, United States

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Clearwater, Florida, United States

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Clearwater, Florida, United States

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Jacksonville, Florida, United States

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Lake City, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Miami Lakes, Florida, United States

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Naples, Florida, United States

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Ocala, Florida, United States

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Ormond Beach, Florida, United States

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Plantation, Florida, United States

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Sarasota, Florida, United States

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Tamarac, Florida, United States

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Tampa, Florida, United States

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Tampa, Florida, United States

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Winter Park, Florida, United States

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Suwanee, Georgia, United States

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West Des Moines, Iowa, United States

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Lexington, Kentucky, United States

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Zachary, Louisiana, United States

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Baltimore, Maryland, United States

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Baltimore, Maryland, United States

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Burlington, Massachusetts, United States

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Farmington Hills, Michigan, United States

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Garden City, Michigan, United States

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Grand Rapids, Michigan, United States

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Chesterfield, Missouri, United States

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Hannibal, Missouri, United States

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St Louis, Missouri, United States

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St Louis, Missouri, United States

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Kalispell, Montana, United States

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Mount Kisco, New York, United States

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New Bern, North Carolina, United States

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Cleveland, Ohio, United States

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Marion, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Tulsa, Oklahoma, United States

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Medford, Oregon, United States

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Portland, Oregon, United States

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Camp Hill, Pennsylvania, United States

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DuBois, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Scottdale, Pennsylvania, United States

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Smithfield, Pennsylvania, United States

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Lancaster, South Carolina, United States

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Spartanburg, South Carolina, United States

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Rapid City, South Dakota, United States

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Chattanooga, Tennessee, United States

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Franklin, Tennessee, United States

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Johnson City, Tennessee, United States

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Boerne, Texas, United States

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Dallas, Texas, United States

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Denison, Texas, United States

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El Paso, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Kingwood, Texas, United States

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Lewisville, Texas, United States

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Mansfield, Texas, United States

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McKinney, Texas, United States

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Pearland, Texas, United States

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Colchester, Vermont, United States

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Norfolk, Virginia, United States

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Williamsburg, Virginia, United States

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Morgantown, West Virginia, United States

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Madison, Wisconsin, United States

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Alberdi, Argentina

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CABA, Argentina

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Capital Federal, Argentina

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Ciudad de Buenos Aires, Argentina

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Ciudad de Buenos Aires, Argentina

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Mar del Plata, Argentina

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Mar del Plata, Argentina

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Mendoza, Argentina

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Ranelagh, Argentina

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Rosario, Argentina

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San Miguel de Tucumán, Argentina

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Cairns, Australia

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Norwood, Australia

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Osborne Park, Australia

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South Brisbane, Australia

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Wollongong, Australia

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Dupnitsa, Bulgaria

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Haskovo, Bulgaria

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Plovdiv, Bulgaria

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Sofia, Bulgaria

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Stara Zagora, Bulgaria

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Veliko Tarnovo, Bulgaria

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Yambol, Bulgaria

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Edmonton, Alberta, Canada

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Winnipeg, Manitoba, Canada

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Truro, Nova Scotia, Canada

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Ajax, Ontario, Canada

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Burlington, Ontario, Canada

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Guelph, Ontario, Canada

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Hamilton, Ontario, Canada

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Stoney Creek, Ontario, Canada

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Québec, Quebec, Canada

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Saint-Charles-Borromée, Quebec, Canada

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Sherbrooke, Quebec, Canada

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Trois-Rivières, Quebec, Canada

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Trois-Rivières, Quebec, Canada

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Victoriaville, Quebec, Canada

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Saskatoon, Saskatchewan, Canada

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Chile, Chile

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Concepción, Chile

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Santiago, Chile

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Santiago, Chile

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Santiago, Chile

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Talca, Chile

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Temuco, Chile

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Viña del Mar, Chile

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Baotou, China

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Beijing, China

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Beijing, China

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Beijing, China

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Beijing, China

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Changchun, China

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Changsha, China

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Changsha, China

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Chengdu, China

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Chengdu, China

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Chengdu, China

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Chongqing, China

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Fuzhou, China

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Guangzhou, China

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Guangzhou, China

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Hangzhou, China

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Hohhot, China

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Jinan, China

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Kunming, China

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Linhai, China

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Nanchang, China

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Nanjing, China

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Nanning, China

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Qingdao, China

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Shanghai, China

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Shanghai, China

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Shenyang, China

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Wuhan, China

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Wuhan, China

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Xuzhou, China

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Zhengzhou, China

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Aalborg, Denmark

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Aarhus, Denmark

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Esbjerg, Denmark

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Hvidovre, Denmark

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Odense C, Denmark

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Roskilde, Denmark

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Ahrensburg, Germany

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Bendorf, Germany

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Berlin, Germany

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Berlin, Germany

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Berlin, Germany

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Berlin, Germany

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Berlin, Germany

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Berlin, Germany

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Darmstadt, Germany

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Halle, Germany

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Hanover, Germany

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Landsberg, Germany

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Leipzig, Germany

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Lübeck, Germany

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Marburg, Germany

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Obertshausen, Germany

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Rosenheim, Germany

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Schleswig, Germany

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Wiesbaden, Germany

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Witten, Germany

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Athens, Greece

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Athens, Greece

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Athens, Greece

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Ioannina, Greece

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Thessaloniki, Greece

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Thessaloniki, Greece

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Balassagyarmat, Hungary

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Budapest, Hungary

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Debrecen, Hungary

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Edelény, Hungary

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Encs, Hungary

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Gödöllő, Hungary

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Hajdúnánás, Hungary

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Nyíregyháza-Sóstóhegy, Hungary

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Pécs, Hungary

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Szombathely, Hungary

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Törökbálint, Hungary

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Belagavi, India

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Coimbatore, India

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Dehradun, India

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Dwārka, India

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Hyderabad, India

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Hyderabad, India

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Kochi, India

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Mumbai, India

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Nagpur, India

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Vijayawada, India

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Busto Arsizio, Italy

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Cuneo, Italy

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Milan, Italy

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Monza, Italy

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Naples, Italy

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Pavia, Italy

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Roma, Italy

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Statte, Italy

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Telese Terme, Italy

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Chiba, Japan

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Fukuoka, Japan

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Fukushima, Japan

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Ginowan-shi, Japan

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Hachioji-shi, Japan

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Hamamatsu, Japan

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Hiroshima, Japan

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Izumi-shi, Japan

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Kamakura, Japan

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Kanazawa, Japan

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Kasuga-shi, Japan

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Kawasaki-shi, Japan

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Kiyosu-shi, Japan

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Kochi, Japan

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Kōtoku, Japan

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Kumamoto, Japan

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Kyoto, Japan

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Maebashi, Japan

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Matsuyama, Japan

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Minoh, Japan

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Minokamo Shi, Japan

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Miura, Japan

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Mizunami-shi, Japan

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Osaka, Japan

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Ōita, Japan

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Sagamihara-shi, Japan

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Sapporo, Japan

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Sasebo-shi, Japan

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Shimotsuga-gun, Japan

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Shinjuku-ku, Japan

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Tachikawa-shi, Japan

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Toon-shi, Japan

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Toyota, Japan

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Ube, Japan

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Yokkaichi-shi, Japan

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Yokohama, Japan

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Yokohama, Japan

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Chihuahua City, Mexico

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Durango, Mexico

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Guadalajara, Mexico

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Guadalajara, Mexico

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Mexico City, Mexico

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Mexico City, Mexico

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Monterrey, Mexico

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Monterrey, Mexico

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Monterrey, Mexico

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Monterrey, Mexico

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Lima, Peru

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Lima, Peru

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Lima, Peru

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Lima, Peru

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Lima, Peru

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Lima, Peru

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Lima, Peru

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Lima, Peru

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Bialystok, Poland

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Bydgoszcz, Poland

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Chęciny, Poland

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Elblag, Poland

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Karczew, Poland

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Katowice, Poland

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Katowice, Poland

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Komorniki, Poland

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Ksawerów, Poland

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Lodz, Poland

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Ostróda, Poland

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Piaseczno, Poland

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Poznan, Poland

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Płock, Poland

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Rzeszów, Poland

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Sosnowiec, Poland

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Szczecin, Poland

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Warsaw, Poland

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Anyang-si, South Korea

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Cheongju-si, South Korea

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Chuncheon, South Korea

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Daegu, South Korea

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Daegu, South Korea

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Jeonju, South Korea

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Seongnam-si, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Wŏnju, South Korea

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Benalmádena, Spain

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Granollers, Spain

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Madrid, Spain

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Málaga, Spain

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Mérida, Spain

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Pozuelo de Alarcón, Spain

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Santander, Spain

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Changhua, Taiwan

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Kaohsiung City, Taiwan

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Kaohsiung City, Taiwan

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Taichung, Taiwan

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Taichung, Taiwan

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Taichung, Taiwan

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Taipei, Taiwan

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Taipei, Taiwan

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Taoyuan, Taiwan

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Yung Kang City, Taiwan

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Adana, Turkey (Türkiye)

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Ankara, Turkey (Türkiye)

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Bursa, Turkey (Türkiye)

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İzmit, Turkey (Türkiye)

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Kayseri, Turkey (Türkiye)

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Mersin, Turkey (Türkiye)

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Chernivtsi, Ukraine

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Ivano-Frankivsk, Ukraine

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Ivano-Frankivsk, Ukraine

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Kyiv, Ukraine

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Kyiv, Ukraine

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Kyiv, Ukraine

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Kyiv, Ukraine

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Kyiv, Ukraine

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Lutsk, Ukraine

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Ternopil, Ukraine

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Uzhhorod, Ukraine

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Bradford, United Kingdom

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Cottingham, United Kingdom

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Glasgow, United Kingdom

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Harrow, United Kingdom

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London, United Kingdom

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London, United Kingdom

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Newcastle upon Tyne, United Kingdom

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Thetford, United Kingdom

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Wythenshawe, United Kingdom

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Da Nang, Vietnam

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Dong Thập, Vietnam

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Hanoi, Vietnam

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Hanoi, Vietnam

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Hanoi, Vietnam

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Ho Chi Minh City, Vietnam

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Huế, Vietnam

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Rach Gia, Vietnam

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NCT07082738

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