A Study of AC-101 Tablets in Participants With Moderate to Severe Active Ulcerative Colitis

This study is testing a new tablet called AC-101 for people with moderate to severe ulcerative colitis — a condition where the large intestine becomes chronically inflamed, causing frequent bloody diarrhea and cramping. Researchers want to see if this new medication can reduce inflammation and improve symptoms. **You may be eligible if...** - You have been diagnosed with ulcerative colitis for at least 3 months, confirmed by an internal camera exam (endoscopy) - Your disease is currently active and causing symptoms like rectal bleeding and frequent bowel movements - Your disease extends at least 15 cm inside the bowel - You have tried at least one conventional treatment that has not worked well enough **You may NOT be eligible if...** - You have had severe complications like a toxic colon or recent surgery for colitis - You have a current serious infection - You have recently used biologic medications or certain immunosuppressants - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.