Renal Artery Denervation Assessment Without Antihypertensive Medication Regimen (RADAR)

This study is testing a minimally invasive procedure called renal artery denervation (RDN) to lower blood pressure. The procedure uses a catheter to gently disrupt nerves around the kidney arteries that contribute to high blood pressure, potentially reducing the long-term need for medications. **You may be eligible if...** - Your blood pressure remains high (systolic at or above 150 mmHg) despite taking 1 or 2 blood pressure medications - Your 24-hour blood pressure monitoring also shows elevated readings - You are willing to temporarily stop your blood pressure medications for about 13 weeks during the study **You may NOT be eligible if...** - You have abnormal kidney artery anatomy - You have already had a renal denervation procedure - Your kidney function is significantly reduced - You have other serious conditions affecting the kidneys, heart, or blood vessels Talk to your doctor to see if this trial is right for you.