RecruitingEarly Phase 1NCT07085559

Safety and Efficacy of Metabolically Armed BCMA CAR-T Cells (Meta10-BCMA) in the Treatment of r/r Plasma Cell Neoplasms Clinical Research


Sponsor

Anhui Provincial Hospital

Enrollment

36 participants

Start Date

Jun 23, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A Study of Metabolically Armed BCMA CAR-T Cells Therapy for Patients With Relapsed and/or Refractory Plasma Cell Neoplasms.


Eligibility

Min Age: 19 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of CAR-T cell therapy called Meta10-BCMA — a treatment where a patient's own immune cells are genetically re-engineered in the lab to attack plasma cell cancers — in people with multiple myeloma or related plasma cell cancers that have stopped responding to multiple prior treatments. **You may be eligible if...** - You are between 19 and 75 years old - You have been diagnosed with relapsed or refractory multiple myeloma, plasma cell leukemia, or AL amyloidosis - You have already received at least 3 prior lines of treatment, including drugs from proteasome inhibitor and immunomodulatory agent classes - Your cancer cells test positive for a protein called BCMA **You may NOT be eligible if...** - You have serious active infections - You have severe heart, lung, liver, or kidney dysfunction - You have cancer that has spread to the brain - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMetabolically Armed BCMA CAR-T cells.

Each subject receive metabolically armed BCMA CAR- T cells by intravenous infusion.


Locations(1)

Anhui Provincial Hospital

Hefei, Anhui, China

View Full Details on ClinicalTrials.gov

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NCT07085559


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