RecruitingEarly Phase 1NCT07085559
Safety and Efficacy of Metabolically Armed BCMA CAR-T Cells (Meta10-BCMA) in the Treatment of r/r Plasma Cell Neoplasms Clinical Research
Sponsor
Anhui Provincial Hospital
Enrollment
36 participants
Start Date
Jun 23, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
A Study of Metabolically Armed BCMA CAR-T Cells Therapy for Patients With Relapsed and/or Refractory Plasma Cell Neoplasms.
Eligibility
Min Age: 19 YearsMax Age: 75 Years
Plain Language Summary
Simplified for easier understanding
This study is testing a new type of CAR-T cell therapy called Meta10-BCMA — a treatment where a patient's own immune cells are genetically re-engineered in the lab to attack plasma cell cancers — in people with multiple myeloma or related plasma cell cancers that have stopped responding to multiple prior treatments.
**You may be eligible if...**
- You are between 19 and 75 years old
- You have been diagnosed with relapsed or refractory multiple myeloma, plasma cell leukemia, or AL amyloidosis
- You have already received at least 3 prior lines of treatment, including drugs from proteasome inhibitor and immunomodulatory agent classes
- Your cancer cells test positive for a protein called BCMA
**You may NOT be eligible if...**
- You have serious active infections
- You have severe heart, lung, liver, or kidney dysfunction
- You have cancer that has spread to the brain
- You are pregnant or breastfeeding
Talk to your doctor to see if this trial is right for you.
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
DRUGMetabolically Armed BCMA CAR-T cells.
Each subject receive metabolically armed BCMA CAR- T cells by intravenous infusion.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07085559
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