RecruitingPhase 2NCT07085988

Effect of Nutritional Management on Patients With Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma

Nutritional Management During Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma Has an Impact on Immunonutritional Status and Therapeutic Phase Toxicity and Prognostic Effects


Sponsor

Jiangxi Provincial Cancer Hospital

Enrollment

109 participants

Start Date

Jan 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Nasopharyngeal carcinoma (NPC) is a malignant tumor that develops in the nasopharyngeal mucosal epithelium. Due to the disease itself and the impact of anti-tumor therapy, malnutrition has become a common clinical complication in patients with NPC, among which NPC patients receiving concurrent chemoradiotherapy are one of the groups with the highest incidence of malnutrition, and malnutrition seriously affects the prognosis of NPC patients. Nutritional management throughout the course has a positive impact on the prognosis and life management of NPC patients. As an immune-enhancing oral nutritional preparation, it is helpful to maintain the weight and immune function of patients with nasopharyngeal carcinoma during concurrent chemoradiotherapy, reduce the degree of treatment-related side effects during concurrent chemoradiotherapy for nasopharyngeal carcinoma, and delay the occurrence of acute side effects. The purpose of this study was to investigate the effect of rapid rapid rapid improvement of patients' immune status during concurrent chemoradiotherapy, and to further evaluate its impact on patients' weight, prognosis, treatment-related toxic side effects, and quality of life. In this study, 109 patients with nasopharyngeal carcinoma who received concurrent chemoradiotherapy in our hospital are planned to be included, and all patients in this group will be given oral tachyphin at a standard dose from the first day of radiotherapy. The nutritional immune status of the patient was assessed at different points during the treatment period.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing the best approach to managing nutrition in patients with nasopharyngeal carcinoma (a type of head and neck cancer) who are receiving combined chemotherapy and radiation therapy. Treatment often makes it very difficult to eat, and good nutrition support may help patients tolerate treatment better and recover faster. **You may be eligible if...** - You have been diagnosed with nasopharyngeal carcinoma confirmed by biopsy (Stage II to IVa) - You are scheduled to receive concurrent chemotherapy and radiation - You are 18 or older - You are nutritionally adequate at baseline - Your blood counts and organ function are adequate - You can take nutrition by mouth or through a feeding tube **You may NOT be eligible if...** - You have already started treatment for this cancer - You have serious nutritional problems or malnutrition at baseline - You have significant organ dysfunction (liver, kidney, or bone marrow) - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERRapid glitter

Patients with nasopharyngeal carcinoma are given rapid gamin during concurrent chemoradiotherapy


Locations(1)

Jiangxi Cancer Hospital

Nanchang, Jiangxi, China

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NCT07085988


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