RecruitingNCT07086014

Methamphetamine Cue-reactivity

Cue Reactivity Modulation in MSM With Methamphetamine Use Disorder

Sponsor

Icahn School of Medicine at Mount Sinai

Enrollment

88 participants

Start Date

Aug 19, 2024

Study Type

OBSERVATIONAL

Conditions

Methamphetamine Use Disorder

Summary

In this observational cohort study, the researchers propose to first identify a psychophysiological marker of methamphetamine cue-reactivity and its incubation with abstinence from methamphetamine use (MUD) and examine group-differences between men who have sex with men (MSM) and non-MSM MUD. The primary objective is to identify psychophysiological markers of methamphetamine (MA) cue-reactivity and its abstinence incubation. The secondary objective is to examine group-differences in methamphetamine use disorder (MUD) individuals between homosexual men (MSM) and heterosexual men (non-MSM). The primary endpoint is to assess incubation of cue-reactivity longitudinally with its reduction in cognitive reappraisal, and the secondary endpoint is to examine the impact of cognitive reappraisal on clinical outcomes of methamphetamine use disorder (MUD) in homosexual men (MSM). 2-year long study. Screening and enrollment will be done at different locations of the Addiction Institute of Mount Sinai. The EEG session will be done at Icahn School of Medicine at Mount Sinai. Participation in the research study will be for a single EEG session.

Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 60 Years

Inclusion Criteria7

Ability to understand and give informed consent
Identify as either MSM or non-MSM
Males; Age 18-60
DSM-5 Diagnosis of MUD (Methamphetamine Use Disorder)
Have appropriate abstinence duration \[i.e., current Methamphetamine users (MA): 2 weeks (range: 1-3 weeks); MA-abstinent: 3 months (range: 2-4 months)\]
Treatment-seeking MUD must be in a treatment facility for substance use disorder, with MA as the primary drug (at the first visit)
Treatment-seeking MUD must be abstinent from MA use for approximately 2 weeks (range: 1-3 weeks) at enrollment.