RecruitingNot ApplicableNCT07086131

A Study Investigating the Impact of IMT With CR On Exercise Responses In HF

Impact Of Adding Inspiratory Muscle Training To Cardiac Rehabilitation On Exercise Responses In Heart Failure

Sponsor

Mayo Clinic

Enrollment

70 participants

Start Date

Sep 4, 2025

Study Type

INTERVENTIONAL

Conditions

Heart Failure With Reduced Ejection Fraction

Summary

The purpose of this study is to compare the impact of inspiratory muscle training (IMT) combined with cardiac rehabilitation (CR) on cardiovascular function in patients with heart failure.

Eligibility

Min Age: 18 Years

Exclusion Criteria12

sustained ventricular tachycardia and/or ventricular fibrillation within 21 days of visit 1;
second or third degree heart block;
body mass index \>45 kg/m2;
current smokers and/or smoking history \>30 pack years;
pregnant women (testing will be done by research team if requested);
glomerular filtration rate of \<30 mL/min/1.73m2 (initial screen via clinical record within the past 6 months and this will be assessed on Visit 1);
individuals who are not able to engage in exercise;
symptomatic peripheral artery disease;
asthmatic patients with a low symptom perception and suffer frequency, severe exacerbations or with an abnormally low perception of dyspnea;
ruptured eardrum or any other condition of the ear;
history of spontaneous pneumothorax or osteoporosis with a history of rib fractures;
history of lung disease.

Interventions

DEVICEPowerbreathe

The breathing training will consist of using the PowerBreathe for 12 weeks. The PowerBreathe is an inspiratory pressure threshold trainer. The valve blocks the airflow until the threshold pressure is achieved by breathing in forcefully into the device.