RecruitingPhase 1NCT07086677

A Study to Learn About How a New Pneumococcal Vaccine Works in Adults

A PHASE 1, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN STUDY TO DESCRIBE THE SAFETY AND TOLERABILITY OF A MULTIVALENT PNEUMOCOCCAL CONJUGATE VACCINE IN ADULTS

Sponsor

Pfizer

Enrollment

372 participants

Start Date

Jul 22, 2025

Study Type

INTERVENTIONAL

Conditions

Streptococcus Pneumoniae

Summary

The purpose of this study is to learn about the safety and tolerability of a pneumococcal vaccine in adults. Participants will receive either: * an experimental PG4 vaccine * a PG4 vaccine comparator * a standard 20vPnC vaccine comparator * placebo. A placebo does not have any medicine in it but looks just like the study medicine. Participants will take part in this study for up to 18 months depending on which group they are assigned to. During this time, the participants will receive up to two doses of study vaccine or comparator and take part in follow-up visits. At these clinic visits, participants will be asked if any side effects were experienced. The participants will also have to give blood samples during clinic visits.

Eligibility

Min Age: 65 YearsMax Age: 84 Years

Plain Language Summary

Simplified for easier understanding

This study is testing how well a new pneumococcal vaccine works in adults by measuring the body's immune response after vaccination. Pneumococcal vaccines protect against serious infections like pneumonia, meningitis, and bloodstream infections caused by the bacterium Streptococcus pneumoniae. **You may be eligible if...** - You are a generally healthy adult - You have never received a pneumococcal vaccine, OR your last one was more than 5 years ago - You are in good health as determined by a medical review **You may NOT be eligible if...** - You have had a confirmed invasive Streptococcus pneumoniae infection in the past (such as bacterial meningitis) - You received a pneumococcal vaccine within the last 5 years - You have significant immune system problems or allergies to vaccine components Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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