RecruitingNot ApplicableNCT07087587
Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):
Sponsor
The Cleveland Clinic
Enrollment
20 participants
Start Date
Aug 25, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
A pilot N-of-1 randomized controlled trial evaluating the effectiveness of a personalized CPAP intervention in reducing atrial fibrillation (AF) burden and improving AF-related quality of life in patients with moderate to severe obstructive sleep apnea (OSA).
Eligibility
Min Age: 18 YearsMax Age: 85 Years
Inclusion Criteria6
- Informed consent
- Age 18-85 years
- High burden paroxysmal AF (≥1%)
- Moderate-severe OSA (AHI ≥ 15)
- Implanted device with atrial diagnostics
- Enrolled in remote monitoring
Exclusion Criteria7
- AF ablation \<6 months
- Valvular abnormalities
- Excessive daytime sleepiness in safety-critical jobs
- Plans for ablation during study
- Non-CPAP OSA treatment
- Recent device implantation (\<6 months)
- Central sleep apnea
Interventions
DEVICECPAP
CPAP will be randomized 2 weeks on 2 weeks off for 12 weeks total
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT07087587