RecruitingPhase 1NCT07092748

A Phase Ia/ Ib Study of HS387 in Subjects With Advanced Solid Tumors

A Phase I Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of HS387 in Subjects With Advanced Solid Tumors

Sponsor

Zhejiang Hisun Pharmaceutical Co. Ltd.

Enrollment

110 participants

Start Date

Jul 15, 2025

Study Type

INTERVENTIONAL

Conditions

Advanced Solid Cancers

Summary

This is a Phase Ia/Ib, dose escalation and dose expansion study to evaluate the safety, tolerability, PK, and preliminary efficacy of HS387 in subjects with advanced solid tumors. It includes two parts: the dose escalation study (Phase Ia) and the dose expansion study (Phase Ib)

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria7

Men or women ≥18 years old and ≤75 years old.
Subjects with advanced solid tumors who have failed or are intolerant to standard treatment, or have no standard therapy.
Survival expectation is ≥ 3 months.
Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1.
Phase Ⅰa: Subjects with advanced solid tumors have at least one evaluable lesion according to RECIST 1.1. Phase Ⅰb: Subjects with advanced solid tumors have at least one measurable lesion according to RECIST 1.1.
Subjects with adequate organ function at the time of screening.
Serum pregnancy test (for female of childbearing potential) negative prior to first dosing of study treatment. Male and female subjects of childbearing potential must agree to use effective methods of contraception throughout the study and for 3 months after the last dose of the investigational product.

Exclusion Criteria11

Subjects will be excluded if they meet any of the following criteria:
Has received other investigational drugs or treatments not yet approved for marketing within 4 weeks prior to the first administration.
Has active infection.
Has meningeal metastases or symptomatic central nervous system (CNS) metastases.
Significant impairment of oral drug absorption.
Has interstitial lung disease.
Pregnant or lactating women.
Known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation.
Has a major surgical procedure within 4 weeks prior to the first administration.
Has a treatment history of KIF18A inhibitor.
In the opinion of the Investigator, there are other factors that the subject is unsuitable for participation in this clinical study.