RecruitingNot ApplicableNCT07095140

Studying the Effects of Nicotine Concentration and Flavor on Alcohol Use in Young Adults

Assessing Co-Use of Oral Nicotine Pouches and Alcohol Among Young Adults


Sponsor

Ohio State University Comprehensive Cancer Center

Enrollment

20 participants

Start Date

Sep 3, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial studies the use of both (co-use) oral nicotine pouches (ONPs) and alcohol among young adults and whether ONP nicotine concentration and flavor affect alcohol use. The co-use of nicotine and alcohol has grown among young adults and the increase in ONP use among young adults may be a contributing factor. ONPs do not contain tobacco leaf and may reduce cancer risk for those who switch from traditional tobacco products (e.g., cigarettes, moist snuff) to ONPs. However, given that alcohol is a cancer-causing agent, using ONPs might increase alcohol use among young adults, which may cause an increase in their risk of cancer. ONPs come in different nicotine concentrations and flavors, with young adults expressing a preference in nicotine concentration or flavor for use while drinking. The different nicotine concentrations and flavors could lead users to drink more or longer. Studying the co-use of ONPs and alcohol among young adults may help researchers understand whether ONP nicotine concentrations and flavors affect alcohol use. This information may be used to help guide future ONP regulations and cancer prevention interventions targeted to young adults.


Eligibility

Min Age: 21 YearsMax Age: 30 Years

Inclusion Criteria6

  • -30 years old
  • Use ONPs daily
  • Drink alcohol at least three days/week
  • Read and speak English
  • Own an iPhone (required for BACtrack Skyn wristband)
  • Used 6 mg nicotine concentration ONPs on at least 20 days of past month

Exclusion Criteria5

  • Use of other tobacco products > 10 days/month
  • Unstable or significant medical condition
  • Unstable or significant psychiatric conditions (past and stable conditions will be allowed)
  • History of cardiac event or distress within the past three months
  • Currently pregnant, planning to become pregnant within six months, or breastfeeding (all participants assigned female at birth will take a pregnancy test at each clinic visit before provision of study products; a negative test will be needed to proceed with product sampling)

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Interventions

OTHEREcological Momentary Assessment

Complete EMAs

OTHERMonitoring

Wear alcohol monitoring wristband

DRUGNicotine Oral Pouch

Receive ONPs

OTHERSurvey Administration

Ancillary studies


Locations(1)

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

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NCT07095140


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