RecruitingNot ApplicableNCT07095556

Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva

Impact of Nd: YAG Laser Photobiostimulation on Healing of Gingiva Following Tooth Extraction and Alveolar Ridge Preservation

Sponsor

Medical University of South Carolina

Enrollment

39 participants

Start Date

Nov 5, 2025

Study Type

INTERVENTIONAL

Conditions

Post-operative Pain Management Wound Healing and Prevention Oral Inflammation Photobiomodulation Tooth Extraction Site Healing

Summary

The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation. Investigators plan to assess the impact of laser treatment on wound healing by measuring salivary biomarkers, gingival wound size and surveying for the use of pain reduction and patient satisfaction. The intervention group will receive extraction and alveolar ridge preservation with Nd-YAG laser photobiostimulation on days 1, 3, and 7 following extraction and socket preservation, while the control group will receive the standard of care extraction and alveolar ridge preservation without the laser

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Participants who are ≥ 18 years old,
Patients who are scheduled for the treatment of tooth extraction and alveolar ridge preservation (ARP)
No contraindications for tooth extraction and alveolar ridge preservation based on electronic health records.
Participants who can express the level of pain
Participants who self-report "not pregnant"

Exclusion Criteria6

Untreated periodontal disease
Acute infection of the teeth
Use of antibiotics within the last three months.
Pregnant or lactating women
Use of bisphosphonates based on EHR
Alveolar bone defects occurred or were detected during tooth extraction

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Interventions

OTHERLow-level laser therapy

The low-level laser applications will be made on the same day as the standard of care treatment (day 1), and then day 3, and day 7 by a study team member who is trained in the use of the laser device. The laser photobiostimulation will be applied using LightWalker® laser (FOTONA), with following settings, Nd:YAG laser 1064 nm, MSP modality (pulse duration), 0.5 W (power), 10 Hz (frequency), 1 min/ 1 cm2 spot using Genova handpiece from buccal, lingual, and occlusal aspects. The Genova handpiece will be placed 1 cm away from gingival tissue. Participants and operators will wear glasses to protect their eyes from laser beam in all sessions.