RecruitingNot ApplicableNCT07101458

The Eswatini PRISM Study on Adolescents Living With HIV

Feasibility and Acceptability of the Promoting Resilience in Stress Management (PRISM) Intervention Among Adolescents (10 - 19 Years) Living With HIV in Eswatini: A Single Site, Single-Blind, Randomized Controlled Pilot Clinical Trial

Sponsor

Eswatini Nazarene Health Institutions

Enrollment

140 participants

Start Date

Dec 30, 2025

Study Type

INTERVENTIONAL

Conditions

Psychological Stress Human Immunodeficiency Virus

Summary

Adolescents living with Human Immunodeficiency Virus (ALHIV) are at an increased risk of experiencing psychological distress and adverse mental health outcomes, particularly in low- to middle-income countries (LMICs). Although interventions aimed at promoting resilience have demonstrated potential in enhancing psychosocial outcomes among adolescents with chronic illnesses in high-income settings, there is a paucity of evidence from LMICs. This study protocol aims to outline a comprehensive framework for evaluating the feasibility, acceptability, and effectiveness of the Promoting Resilience in Stress Management (PRISM) intervention in comparison to standard psychosocial care among ALHIV in a LMIC, such as Eswatini (formerly known as Swaziland). Additionally, it seeks to gather qualitative insights from both participants and PRISM coaches regarding the PRISM program. Exploratory outcomes under investigation are psychological distress, resilience, and HIV health-related quality of life. We hypothesise that: 1. Participants in the PRISM intervention group will experience reduced psychological distress compared to those in the control arm. 2. Participants in the PRISM intervention group will report improved HIV health-related quality of life after receiving the intervention compared to the control group. 3. Participants in the intervention arm will have higher resilience scores after receiving the intervention compared to those receiving usual psychosocial care.

Eligibility

Min Age: 10 YearsMax Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This study in Eswatini is testing a mental health support program called PRISM for teenagers living with HIV who are experiencing significant psychological distress, such as anxiety or depression. **You may be eligible if...** - You are between 10 and 19 years old and living with HIV - You are able to participate in interviews and conversations - You are experiencing moderate to high psychological distress based on a standard screening questionnaire **You may NOT be eligible if...** - You don't want to participate - Your parent or guardian (if you're under 18) does not agree to your participation - You are currently having thoughts of suicide (the PRISM program is not designed to address suicidal thoughts, and you would be referred to appropriate care) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALPromoting Resilience in Stress Management intervention

PRISM is a manualized, skills-based training program comprised of three 60-minute, one-on-one sessions designed to build resilience resources (stress management, goal-setting, cognitive-reframing, and meaning-making) in adolescents and young adults (AYAs). The sessions are scheduled every 1-2 weeks based on participant preference. In this study, the PRISM sessions will be facilitated by trained nurses who hold bachelor's degrees in Nursing Science with a specialisation in mental health.