RecruitingPhase 2NCT07104630

Pulmonary Rehabilitation in Advanced Lung Cancer Survivors


Sponsor

Case Comprehensive Cancer Center

Enrollment

85 participants

Start Date

Mar 16, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study is for people who have previously been diagnosed with advanced stage non-small cell lung cancer (NSCLC). Many people with advanced stage NSCLC have trouble breathing and feel tired. People may be eligible for this study if they have advanced stage NSCLC and feel short of breath some of the time. NSCLC survivors may also experience things like fatigue and a lower quality of life. Pulmonary rehabilitation is a type of supportive treatment that may improve these symptoms. This study has two parts. The first part is a randomized trial where half of the participants receive eight weeks of pulmonary rehabilitation. The other half of participants do not do pulmonary rehabilitation and instead receive the treatment that their doctors would normally recommend. The purpose of this part of the research study is to understand if pulmonary rehabilitation can help people with advanced stage NSCLC have better functioning and less shortness of breath. The other part of the research study is an interview study. The purpose of doing interviews is to understand any challenges or obstacles that people with advanced stage NSCLC may have regarding pulmonary rehabilitation, as well as oncology care providers have with their participants going to pulmonary rehabilitation.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a structured pulmonary rehabilitation program — breathing exercises and physical training — can reduce breathlessness and improve quality of life in people living with advanced lung cancer. **You may be eligible if...** - You are 18 or older with Stage III or IV non-small cell lung cancer being treated to manage symptoms (not cure) - You have been stable (no signs of cancer progression) for the past 3 months - You feel noticeably short of breath in daily life (mMRC score of 2 or higher) - You can speak and read English **You may NOT be eligible if...** - You are currently receiving combined chemotherapy and radiation aimed at curing your cancer - Your cancer is currently progressing or worsening - You have a mental condition that prevents you from completing the study requirements - You are at high risk of bone fractures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALPulmonary Rehabilitation (PR)

Participants will complete an 8-week course of PR, administered by certified respiratory therapists. For each week of the course, participants will attend two PR sessions. Each session will review topics such as physical function, nutrition, and psychosocial health. Participants will also be given an "exercise prescription" to complete throughout the 8-week course. The "exercise prescription" will include individualized cardiopulmonary activities.

OTHERNo intervention: Usual care

Participants will receive standard-of-care, publicly available education on Nutrition and Cancer Survivors and Physical Activity and Cancer Survivors published by the American Institute for Cancer Research.


Locations(1)

University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center

Cleveland, Ohio, United States

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NCT07104630


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