Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)

This study is testing whether a low dose of osilodrostat — a drug that blocks excess cortisol production — can help people with mild autonomous cortisol secretion (MACS), a condition where small benign adrenal growths produce slightly too much of the stress hormone cortisol. **You may be eligible if...** - You are 18 or older - You have been diagnosed with MACS based on adrenal imaging and abnormal cortisol suppression tests - You have at least one related health problem such as obesity, high blood pressure, high blood sugar, high cholesterol, or weak bones **You may NOT be eligible if...** - You have adrenal cancer or suspected malignancy - You have other causes of high cortisol (such as Cushing's syndrome from another source) - You have liver problems or are taking medications that strongly interact with osilodrostat - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.