Total Intravenous Anesthesia in Patients Undergoing Craniotomy
Comparison of Dexmedetomidine Versus Fentanyl or Magnesium Sulphate as Adjuncts to Propofol-Based Total Intravenous Anesthesia in Patients Undergoing Craniotomy
Zagazig University
108 participants
Aug 10, 2025
INTERVENTIONAL
Conditions
Summary
Craniotomy presents true anesthetic challenges, mainly due to the need to optimize cerebral perfusion, facilitate brain relaxation, achieve rapid emergence for neurologic assessment, and minimize perioperative complications.
Eligibility
Inclusion Criteria5
- Patient acceptance.
- Physical status: American Society of Anesthesiologists Physical Status (ASA) 1\& II.
- Body mass index ≤ 30 kg/m2.
- Type of operation: elective craniotomy for brain tumor resection.
- Duration of surgery: within 4 hours.
Exclusion Criteria4
- Patient with hemodynamic instability or anticipated postoperative mechanical ventilation.
- Patients with a known history of allergy to the study drugs.
- Advanced hepatic, renal, cardiovascular, and neurologic diseases.
- Patients with chronic opioid use.
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Interventions
Dexmedetomidine as an adjunct to total intravenous anesthesia.
Fentanyl as an adjunct to total intravenous anesthesia.
Magnesium sulphate as an adjunct to total intravenous anesthesia.
Locations(1)
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NCT07105618