RecruitingEarly Phase 1NCT07106814

Safety and Efficacy of Metabolically Armed Tumor-lnfiltrating Lymphocytes (Meta10-TIL) for the Treatment of Advanced Solid Tumors


Sponsor

Anhui Provincial Hospital

Enrollment

36 participants

Start Date

Aug 29, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A Study of Metabolically Armed Tumor-Infiltrating Lymphocytes (Meta10-TIL) Therapy for Patients With Advanced Solid Tumors


Eligibility

Min Age: 19 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of immune cell therapy called Meta10-TIL (tumor-infiltrating lymphocytes that have been metabolically enhanced) for people with advanced solid tumors, particularly cervical cancer and other hard-to-treat cancers. These are the patient's own immune cells that are removed, enhanced in a lab, and then put back into the body to fight cancer. **You may be eligible if:** - You are between 18 and 70 years old - You have a confirmed advanced solid tumor (especially recurrent or metastatic cervical cancer) - You have already received at least one prior line of treatment - You have not had more than 3 prior systemic therapies - Your cancer cannot be cured by surgery or radiation **You may NOT be eligible if:** - You have not yet received any prior treatment - You have had more than 3 prior systemic therapies - You have serious organ problems that would make this treatment unsafe - You have active autoimmune disease or serious infections Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMetabolically Armed TIL cells

Each subject receive metabolically armed TIL cells by intravenous infusion.


Locations(1)

Anhui Provincial Hospital

Hefei, Anhui, China

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NCT07106814


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