A Study of JNJ-95437446 in Participants With Advanced-Stage Solid Tumors

This study is testing a new drug called JNJ-95437446 in people with advanced non-small cell lung cancer, colorectal cancer, or head and neck squamous cell cancer that has stopped responding to standard treatments. This is an early-phase trial testing different doses to find what works safely. **You may be eligible if:** - You have been diagnosed with advanced or metastatic non-small cell lung cancer, colorectal cancer, or head and neck squamous cell carcinoma - Your cancer has progressed after prior treatment - Your cancer has been tested for specific genetic mutations (EGFR for lung cancer; KRAS/NRAS/BRAF for colorectal cancer) - Your overall health is good (ECOG 0–1) - You have measurable or evaluable disease on imaging **You may NOT be eligible if:** - You have a different type of cancer not listed above - You have not had prior treatment - You have serious organ problems or other active cancers - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.