RecruitingNCT07110324

Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study


Sponsor

Rigshospitalet, Denmark

Enrollment

100 participants

Start Date

Jun 26, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Despite high success rates of hip and knee arthroplasty, up to 20% of patients report moderate-to-severe pain (NRS \> 3) persisting beyond the expected healing period. This investigator-initiated, descriptive cohort study will re-invite approximately 100 consenting patients with persistent postoperative pain-identified from a pool of \~7 000 respondents-to complete standardized assessments of neuropathic (DN4), nociplastic (IASP criteria + Fibromyalgia Survey Questionnaire) and nociceptive (KOOS/HOOS pain domains) pain. Primary outcomes are the prevalence of potential nociplastic pain and the proportion experiencing significant pain in two or more mechanistic categories. Secondary analyses will compare baseline vs. re-evaluated DN4 scores, FSQ and KOOS/HOOS distributions, and examine differences between patients with and without possible neuropathic pain. Findings will inform targeted pre- and postoperative pain management strategies.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at why some people still experience significant pain after total hip replacement, total knee replacement, or partial knee replacement. Researchers want to understand the characteristics of this persistent pain — whether it is joint-related, nerve-related, or something else — to better prevent and treat it. **You may be eligible if...** - You have had a total hip, total knee, or partial knee replacement - You still have moderate to severe pain after the surgery (pain score above 3 out of 10) - You are willing to be contacted for a follow-up assessment **You may NOT be eligible if...** - You have needed a repeat surgery on the same joint - Your joint has dislocated - You have had serious post-surgical complications, such as a joint infection, blood clot, or fracture around the prosthesis - You do not want to be contacted Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.


Locations(1)

Rigshospitalet

Østerbro, København Ø, Denmark

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07110324


Related Trials