RecruitingNCT07110324

Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study


Sponsor

Rigshospitalet, Denmark

Enrollment

100 participants

Start Date

Jun 26, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Despite high success rates of hip and knee arthroplasty, up to 20% of patients report moderate-to-severe pain (NRS \> 3) persisting beyond the expected healing period. This investigator-initiated, descriptive cohort study will re-invite approximately 100 consenting patients with persistent postoperative pain-identified from a pool of \~7 000 respondents-to complete standardized assessments of neuropathic (DN4), nociplastic (IASP criteria + Fibromyalgia Survey Questionnaire) and nociceptive (KOOS/HOOS pain domains) pain. Primary outcomes are the prevalence of potential nociplastic pain and the proportion experiencing significant pain in two or more mechanistic categories. Secondary analyses will compare baseline vs. re-evaluated DN4 scores, FSQ and KOOS/HOOS distributions, and examine differences between patients with and without possible neuropathic pain. Findings will inform targeted pre- and postoperative pain management strategies.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • All patients with persistent moderate-severe pain (NRS\>3) after THA, TKA and UKA
  • Acceptance to be contacted.

Exclusion Criteria4

  • Re-operation
  • Luxation
  • Do not want to be contacted
  • Post-operative complications such as prosthesis infection, thromboembolism or fracture of the prosthesis.

Locations(1)

Rigshospitalet

Østerbro, København Ø, Denmark

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NCT07110324


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