RecruitingNot ApplicableNCT07112521

tDCS Intervention in Breast Cancer Survivors With and Without Obesity Reporting Cognitive Impairment

Evaluating the Efficacy of Home-Based tDCS for Cancer-Related Cognitive Impairment and Its Moderation by Obesity: A Double-Blind Randomized Controlled Trial.


Sponsor

University of Helsinki

Enrollment

40 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this intervention is to investigate whether transcranial Direct Current Stimulation (tDCS) can alleviate Cancer-Related Cognitive Impairment (CRCI) in breast cancer survivors, as measured by changes in brain structures and cognitive performance. To assess the efficacy of tDCS, the investigators will compare outcomes between participants receiving active stimulation and those receiving sham stimulation (a placebo condition where participants believe they are receiving stimulation, but are not). Participants will: * Undergo a baseline MRI session * Receive either active or sham tDCS for six weeks * Undergo a follow-up MRI session * Complete cognitive tests and respond to psychosocial questionnaires before, during, and after the tDCS intervention


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing transcranial direct current stimulation (tDCS) — a non-invasive brain stimulation technique using mild electrical current applied to the scalp — to help breast cancer survivors who experience thinking and memory difficulties (often called 'chemo brain'). The study also looks at whether obesity affects outcomes. **You may be eligible if...** - You are a woman over 18 years old - You have been diagnosed with breast cancer (first diagnosis, adult-onset) within the last 5 years - You completed all active cancer treatments at least 3 months ago - You are fluent in Finnish or English - You are right-handed - You have normal or corrected vision and hearing - You have internet access **You may NOT be eligible if...** - You received cancer treatment (chemo, radiation, surgery, immunotherapy) within the past 3 months - You have a history of childhood cancer - You have dementia, Alzheimer's disease, multiple sclerosis, or Parkinson's disease - You have had a stroke or mini-stroke - You have metal implants (pacemaker, neurostimulator, cochlear implant, metallic eye implants) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICEactive tDCS

The anodal electrode will be placed over the left DLPFC (F3), and the cathodal electrode will be placed over the right supraorbital area (FP2). The current will be gradually ramped up to 2mA over 30 seconds, held constant at 2mA for 29 minutes, and then gradually ramped down to 0mA over the final 30 seconds.

DEVICEsham tDCS

The anodal electrode will be placed over the left DLPFC (F3), and the cathodal electrode will be placed over the right supraorbital area (FP2). The current will be initially ramped up to 2mA over 30 seconds and immediately ramped back down to 0mA.


Locations(1)

Department of Psychology, Faculty of Medicine, University of Helsinki

Helsinki, Uusimaa, Finland

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07112521


Related Trials