Study of Predicting Lymph Node Metastasis of High-risk Prostate Cancer by Artificial Intelligence Multi-omics Analysis

This study is developing an AI-based tool to predict whether high-risk prostate cancer has spread to nearby lymph nodes, using imaging data. Accurate lymph node prediction can help doctors decide whether to remove lymph nodes during surgery and plan radiation therapy, potentially sparing some patients unnecessary procedures. **You may be eligible if...** - You are 50 years or older - You have confirmed prostate adenocarcinoma - You have high-risk features: PSA of 20 or above, or a Gleason score (tumor aggressiveness rating) of 8 or higher - You are in reasonable health (ECOG 0-2) with life expectancy at least 6 months - Your blood counts, liver, kidney, and heart function meet required levels - Your blood pressure is within acceptable range **You may NOT be eligible if...** - You do not meet the PSA or Gleason score thresholds - You have significant heart, liver, or kidney problems outside acceptable ranges - Your blood pressure or blood counts are outside required ranges Talk to your doctor to see if this trial is right for you.