The Efficacy of Temporal Interference Stimulation in the Treatment of Obsessive-Compulsive Disorder

This study is testing temporal interference stimulation (TIS) — a non-invasive brain stimulation method that uses two intersecting electrical fields to target deep brain areas without surgery — as a treatment for obsessive-compulsive disorder (OCD). OCD that hasn't responded to medications is difficult to treat, and TIS may offer a new option. **You may be eligible if...** - You are between 18 and 50 years old - You have a confirmed OCD diagnosis (by DSM-5 criteria) - Your OCD symptoms are severe (Y-BOCS score of 20 or above) - You have tried at least two adequate courses of SSRI medications (common antidepressants used for OCD) without enough benefit - If currently on SSRIs, your dose has been stable for at least 8 weeks - You have at least 9 years of education **You may NOT be eligible if...** - You have any other DSM-5 psychiatric diagnosis (except OCD-related personality disorder) - You have received electroconvulsive therapy in the past 6 months or other brain stimulation recently - You have a neurological disorder or significant medical illness - You have metal implants (pacemaker, stents, cochlear implants) - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.