Effect of Ebastine in Patients With Diarrhea Predominant Irritable Bowel Syndrome
Md. Hazrat Ali
60 participants
Aug 15, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to assess and compare the effect of ebastine and placebo in improving symptoms in patients with diarrhea predominant IBS. It will also assess about the safety of drugs ebastine and placebo by recording the patient reported adverse events. The main questions it aim to answer are: Does drug ebastine and placebo has any effect on patients with IBS-D? What medical problems do participants have when taking drug ebastine and placebo? Researcher will compare effect of drug ebastine and placebo . Participant will: Take drug ebastine 20 mg at night and placebo once daily at night every day for 8 weeks along with lifestyle modifications. After that all two groups will visit the hospital 4 weekly, and their symptoms will be assessed by IBS symptom severity score (IBS-SSS) at baseline, week 4 and week 8. Additionally, patient reported adverse events will be documented.
Eligibility
Inclusion Criteria2
- Age 18 and above
- Patients who meet the Rome IV criteria for IBS-D.
Exclusion Criteria6
- Presence of alarm features: anemia, weight loss, per rectal bleeding, nocturnal frequency, and family history of colonic cancer
- History of major gastrointestinal surgery
- Medical disease that affect the digestive system, such as uncontrolled diabetes, hyperthyroidism, hypothyroidism
- Pregnant and lactating women
- Vehicle drivers, mechanical operators and aerial operators
- Drug abuse or alcohol abuse
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Interventions
Tab. Ebastine 20mg once daily at night
Tab. Placebo once daily at night
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07114055