Symptom Distribution and Pain Sensitization in Carpal Tunnel Syndrome
Evaluation of Central Sensitization Parameters Based on Extra Median Symptom Distribution in Carpal Tunnel Syndrome: A Cross-sectional Study
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
80 participants
Jun 21, 2025
OBSERVATIONAL
Summary
This study aims to compare central sensitization parameters between carpal tunnel syndrome (CTS) patients with extra median symptom distribution and those with typical, median nerve-related symptoms. Extra median sensory spread, observed in some CTS patients beyond the anatomical boundaries of the median nerve, may reflect central sensitization mechanisms. Using the Central Sensitization Inventory and pressure pain threshold measurements, this study will assess whether extra median symptom patterns are associated with increased central sensitization.
Eligibility
Inclusion Criteria4
- Having been diagnosed with carpal tunnel syndrome based on clinical and electrodiagnostic findings
- Being between 18 and 65 years of age
- Being literate
- Agreeing to participate in the study
Exclusion Criteria6
- Having a history of concomitant diabetes, systemic inflammatory disease, active infection, or malignancy
- Being <18 and >65 years of age
- Being illiterate
- Refusing to participate in the study
- Having a disease associated with neuropathic pain, such as polyneuropathy, radiculopathy, or multiple sclerosis
- History of injection or surgery for CTS within the last 6 months
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Interventions
Ultrasonographic evaluation of the median nerve at the carpal tunnel and adjacent levels
Upper extremity nerve conduction studies including median-ulnar sensory and motor responses
Pain pressure threshold is used to measure deep muscular tissue pain sensitivity.
Locations(1)
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NCT07114913