RecruitingNot ApplicableNCT07115914

PSMA PET for Surveillance After Focal Therapy

Prospective Evaluation of PSMA PET Imaging in Surveillance Post-Focal Therapy for Prostate Cancer (PSMA-FT Surveillance Study)


Sponsor

University of Chicago

Enrollment

62 participants

Start Date

Nov 19, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study is about adding PSMA PET (Prostate Specific Membrane Antigen- Positron Emission Tomography) to routine magnetic resonance imaging (MRI) scans to help detect prostate cancer recurrence in men who have undergone focal therapy for prostate cancer. PSMA PET and multiparametric (mpMRI are both imaging tests that help detect prostate cancer in the body. A PSMA PET scan, or prostate-specific membrane antigen positron emission tomography scan, is an imaging test that scans and takes pictures of the prostate. PSMA scans use a specialized radioactive imaging dye that sticks to the proteins that are typically found in prostate cancer cells. This imaging dye helps locate areas of prostate cancer anywhere in the body, both inside and outside prostate. An mpMRI, or a multiparametric (mp) MRI scan, is also an imaging test that scans and takes detailed pictures of the prostate. Unlike regular MRIs, an mpMRI produces a more detailed image of the prostate. Similar to PET scans, mpMRI scans also use an imaging dye that helps the pictures of the prostate appear clearer on scans. This study will be funded by Blue Earth Diagnostics, a molecular imaging company based in England.


Eligibility

Sex: MALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether PSMA PET scans — a highly sensitive nuclear imaging method that targets prostate-specific membrane antigen — can effectively monitor prostate cancer after focal therapy (a treatment that destroys only part of the prostate gland). **You may be eligible if...** - You are male, 18 or older - You have been diagnosed with prostate cancer confirmed by biopsy - You have chosen focal therapy (partial prostate ablation) as your treatment approach - You are scheduled for focal therapy within 6 months - Your cancer has not spread to other parts of the body **You may NOT be eligible if...** - Your cancer has already spread to lymph nodes or distant organs - Your biopsy was performed more than 1 year ago - You are not a candidate for focal therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONPSMA PET/CT scan

A PSMA PET scan, or prostate-specific membrane antigen positron emission tomography scan, is an imaging test that scans and takes pictures of the prostate. PSMA scans use a specialized radioactive imaging dye that sticks to the proteins that are typically found in prostate cancer cells. This imaging dye helps locate areas of prostate cancer anywhere in the body, both inside and outside prostate.


Locations(1)

University of Chicago Medicine Comprehensive Cancer Center

Chicago, Illinois, United States

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NCT07115914


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