Clinical Research on Moderately Hypofractionated Adaptive Postoperative Radiotherapy for High-Risk Endometrial Cancer

This trial is studying a type of focused, adaptive radiation therapy given after surgery for high-risk endometrial cancer. The radiation is delivered in fewer, slightly larger doses per session (hypofractionation) and is adjusted in real time to account for daily changes in anatomy (adaptive radiotherapy). **You may be eligible if...** - You are 18–70 years old - You have been diagnosed with high-risk endometrial cancer (Stage I–IIIC1) based on specific pathological features - You have already had a hysterectomy and salpingo-oophorectomy (removal of the uterus and ovaries) - You are able to complete the planned radiotherapy sessions (ECOG score 0–2) **You may NOT be eligible if...** - You have previously had abdominal or pelvic radiation - Too much time has passed since your surgery before starting radiation - You have been diagnosed with another cancer - You are pregnant or breastfeeding - You have a history of inflammatory bowel disease - You have an active infection Talk to your doctor to see if this trial is right for you.