RecruitingNCT07118137
Memory Deterioration in Alzheimer Disease
Translational Neuroscience CAG for Alzheimer's Disease
Sponsor
Norwegian University of Science and Technology
Enrollment
30 participants
Start Date
Oct 15, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
Semantic AD
Eligibility
Min Age: 55 Years
Inclusion Criteria4
- Confirmed diagnosis based on current ICD criteria for AD or MCI .
- \>55years.
- Norwegian native speaker
- Lives at home and not in a health institution
Exclusion Criteria10
- Patients with severe cognitive impairment that prevents assessment with the selected modalities (planned cut-off: CDR \> 2).
- Presence of brain tumors.
- History of traumatic brain injury.
- History of cranial surgery.
- Contraindications to the selected imaging modalities (e.g., 7T MRI or EEG).
- Diagnosis of other neurodegenerative diseases such as Parkinson's disease or ALS.
- T MRI contraindications:
- Large tattoos close to the head region, permanent makeup or unremoveable piercings
- Certain models of pacemakers (if pacemaker implantet, MRI physicist at 7T-lab will be conferred)
- Implantet metal in body (clips, stents, prothesis, skrews, plates, teeth etc.)
Interventions
DEVICE7T MRI
Resting and activity-based MRI. Dring activity based MRI, the participant will complete tasks testing semantic memory.
DEVICEEEG
Resting-state EEG
BIOLOGICALBlood samples
Blood samples taken for analysis of central blood biomarkers.
BIOLOGICALStool samples
Stool samples collected to identify distinct gut-microbiota compositions between the groups.
DIAGNOSTIC_TESTNeuropsychologic test (MoCA)
Map cognition with clinically well-established neuropsychology test
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07118137
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