RecruitingNCT07118137

Memory Deterioration in Alzheimer Disease

Translational Neuroscience CAG for Alzheimer's Disease


Sponsor

Norwegian University of Science and Technology

Enrollment

30 participants

Start Date

Oct 15, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Semantic AD


Eligibility

Min Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how memory deteriorates in people with Alzheimer's disease (AD) or mild cognitive impairment (MCI) using advanced brain imaging (7T MRI) and electrical brain activity measurements (EEG). The goal is to better understand the biology behind memory loss in these conditions. **You may be eligible if...** - You are over 55 years old - You have a confirmed diagnosis of Alzheimer's disease or mild cognitive impairment (MCI) based on current diagnostic criteria - You are a native Norwegian speaker - You live at home (not in a care facility) **You may NOT be eligible if...** - You have severe cognitive impairment (CDR score above 2) - You have a brain tumor or history of brain surgery - You have had a significant head injury - You have any condition that prevents you from safely undergoing MRI or EEG (e.g., metal implants) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICE7T MRI

Resting and activity-based MRI. Dring activity based MRI, the participant will complete tasks testing semantic memory.

DEVICEEEG

Resting-state EEG

BIOLOGICALBlood samples

Blood samples taken for analysis of central blood biomarkers.

BIOLOGICALStool samples

Stool samples collected to identify distinct gut-microbiota compositions between the groups.

DIAGNOSTIC_TESTNeuropsychologic test (MoCA)

Map cognition with clinically well-established neuropsychology test


Locations(1)

Norwegian University of Sciene and Technology / Norges teknisk-naturvitenskapelige universitet (NTNU)

Trondheim, Trønderlag, Norway

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NCT07118137


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