RecruitingNot ApplicableNCT07118202

TheraBionic P1 Device in Subjects With Advanced Hepatocellular Carcinoma

TheraBionic P1 Device for Patients With Advanced Hepatocellular Carcinoma (HCC) Who Fail First and Second Line Therapy


Sponsor

Barbara Ann Karmanos Cancer Institute

Enrollment

198 participants

Start Date

Oct 20, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if the TheraBionic P1 device given to patients with advanced hepatocellular carcinoma (HCC) who have no standard of care options can affect patients survival. The main questions it aims to answer are: * will the TheraBionic P1 device affect overall survival in advance HCC * the long term safety and tolerability of the TheraBionic P1 device * assessment of how the disease responded to the TheraBionic P1 device


Eligibility

Min Age: 22 Years

Plain Language Summary

Simplified for easier understanding

This study is testing the TheraBionic P1 device — a wearable that delivers very low-level radiofrequency electromagnetic fields — in patients with advanced liver cancer (hepatocellular carcinoma, or HCC) who have already tried multiple treatments. The device is non-invasive and can be used by people with pacemakers or other implants. **You may be eligible if...** - You have advanced liver cancer (HCC) that cannot be treated with local therapies, or that came back after such treatment - You have already tried at least two standard treatment options, or you are no longer able to tolerate further standard therapy - You are in acceptable general health with reasonable organ function **You may NOT be eligible if...** - You have not yet tried available standard treatments - Your liver or overall health function is severely compromised - You are pregnant or breastfeeding - You are unwilling to follow study procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETheraBionic P1

Amplitude-modulated electromagnetic fields will be self-administered and given continuously to patients in three 60-minute treatments per day, administered in the morning, middle of the day, and in the evening


Locations(6)

Karmanos Cancer Institute at McLaren Bay Region

Bay City, Michigan, United States

Karmanos Cancer Institute

Detroit, Michigan, United States

Karmanos Cancer Institute at McLaren Flint

Flint, Michigan, United States

Karmanos Cancer Institute at McLaren Greater Lansing

Lansing, Michigan, United States

Karmanos Cancer Institute at McLaren Lapeer Region

Lapeer, Michigan, United States

Karmanos Cancer Institute at McLaren Central Michigan, Morey Cancer Center

Mount Pleasant, Michigan, United States

View Full Details on ClinicalTrials.gov

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NCT07118202


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