Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM
Combination Oxytocin/Foley Versus Oxytocin Alone for Induction of Labor in Patients With Preterm Prelabor Rupture of Membranes
Eastern Virginia Medical School
80 participants
Jul 14, 2025
INTERVENTIONAL
Conditions
Summary
Data on the optimal mode of labor induction after preterm prelabor rupture of membranes (PPROM) is lacking. Studies have shown no difference between oxytocin and misoprostol use for labor induction in this cohort (1). The preponderance of evidence from term pregnancies suggests that Foley catheter coupled with oxytocin is better than oxytocin alone, with a higher rate of delivery within 24 hours when a Foley catheter followed by oxytocin is compared to oxytocin alone. However, the use of a Foley catheter has not been evaluated in prospective studies on patients with PPROM.
Eligibility
Plain Language Summary
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Interventions
Intravenous oxytocin and a transcervical Foley catheter
Intravenous oxytocin
Locations(1)
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NCT07119398