SMC Radiation Oncology SABR Cohort for Oligometastasis
Cohort Study for Local Stereotactic Body Radiotherapy in Patients With Oligometastatic or Oligoprogressive Cancer
Samsung Medical Center
60 participants
May 1, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to evaluate the efficacy and safety of stereotactic body radiotherapy (SABR) in patients with oligometastatic or oligoprogressive cancer. The main questions it aims to answer are: 1. oncologic outcomes (progression-free survival, local failure rate), 2. patient-reported outcomes, 3. physician-assessed toxicity, and 4. dynamics of circulating tumor DNA (ctDNA) for biomarker analysis.
Eligibility
Inclusion Criteria3
- Performance status (ECOG PS) 0-2
- Diagnosed with metastatic disease
- Confirmed to have oligometastatic/oligoprogressive cancer on imaging performed within 4 weeks (up to 5 lesions)
Exclusion Criteria2
- Patient with a history of prior radiotherapy to the site planned for SABR
- Patients with concomitant brain metastases
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Interventions
Stereotactic body radiotherapy (SABR) using photon or proton beams will be delivered per standard practice (1-5 fractions).
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07121335