Neurofeedback to Reduce Spontaneous Recovery of Threat Expectancy
Reducing Spontaneous Recovery Using Functional Connectivity Based Real-time Functional Magnetic Resonance Imaging Neurofeedback Targeting the Memory Control Network
Trustees of Princeton University
40 participants
Jul 17, 2025
INTERVENTIONAL
Conditions
Summary
This study tests the efficacy of a new behavioral intervention with the goal of reducing spontaneous recovery of threat expectancy in healthy adults. This real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention delivers feedback based on a functional connection between the prefrontal cortex and the hippocampus.
Eligibility
Inclusion Criteria9
- Adults aged 18-50
- No history of psychiatric disorders or neurological disorders affecting the central nervous system.
- Are not currently taking psychoactive medication or drugs of abuse.
- Must be eligible to enter an MRI (i.e., no permanent metal or medical implants)
- Normal color vision
- Right-handed
- Full reading and writing English comprehension
- Must exhibit spontaneous recovery behavior as determined by an experimenter in a prescreening experimental session
- Must be able to provide informed consent
Exclusion Criteria9
- Pregnancy (female participants)
- Outside of age range
- History of psychiatric or neurological disease
- Currently taking psychoactive medication or drugs of abuse
- Color blindness
- Primary left-handedness
- Less than full reading and writing English comprehension
- Do not exhibit spontaneous recovery behavior as determined by an experimenter in a prescreening experimental session
- Refusing to provide informed consent
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Interventions
Active neurofeedback to target a functional connection associated with increased memory control ability
Sham neurofeedback
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07122739