RecruitingPhase 1Phase 2NCT07123454

A Phase I/II Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma

A Modular Phase I/II Open-label, Multicenter Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, Immunogenicity, and Efficacy of AZD4512 Monotherapy or in Combination With Other Anticancer Agent(s), in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma (B-NHL) (Lumi-NHL)


Sponsor

AstraZeneca

Enrollment

91 participants

Start Date

Sep 24, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a Phase I/II open-label, global multicenter study to evaluate the safety and efficacy of AZD4512 monotherapy or in combination with other anticancer agent(s), in participants with Relapsed/Refractory B-cell Non-Hodgkin Lymphoma (B-NHL).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This Phase I/II study is testing a new drug called AZD4512, alone or in combination with other cancer treatments, in people with B-cell Non-Hodgkin Lymphoma (a type of blood cancer) that has returned or stopped responding to previous therapies. **You may be eligible if...** - You are 18 years or older - You have a confirmed diagnosis of B-cell Non-Hodgkin Lymphoma - Your lymphoma has relapsed or is refractory (not responding to prior treatment) - You are in reasonably good physical health overall **You may NOT be eligible if...** - Your lymphoma has spread to the brain or spinal fluid - You have certain specific lymphoma subtypes that are excluded - You have serious active infections or other significant health problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAZD4512

AZD4512 is an antibody-drug conjugate targeting cluster of differentiation 22 (CD22) that will be administered via IV infusion


Locations(22)

Research Site

Irvine, California, United States

Research Site

Jacksonville, Florida, United States

Research Site

Rochester, Minnesota, United States

Research Site

New York, New York, United States

Research Site

New York, New York, United States

Research Site

Cleveland, Ohio, United States

Research Site

Myrtle Beach, South Carolina, United States

Research Site

Franklin, Tennessee, United States

Research Site

Melbourne, Australia

Research Site

Chengdu, China

Research Site

Guangzhou, China

Research Site

Bologna, Italy

Research Site

Milan, Italy

Research Site

Milan, Italy

Research Site

Bunkyō City, Japan

Research Site

Kōtoku, Japan

Research Site

Seoul, South Korea

Research Site

Seoul, South Korea

Research Site

Taichung, Taiwan

Research Site

Taipei, Taiwan

Research Site

London, United Kingdom

Research Site

Newcastle upon Tyne, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT07123454


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