Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns.
Kocaeli City Hospital
210 participants
Jul 23, 2025
INTERVENTIONAL
Conditions
Summary
This study was planned as a single-center, prospective, randomized trial. Adult patients undergoing elective spinal surgery lasting longer than three hours, performed in a neurosurgery operating room, will be evaluated. Patients managed with three different anesthesia methods currently used will be examined for recovery patterns: 1. Total intravenous anesthesia (TIVA), 2. TIVA Combined anesthesia with sevoflurane and intravenous agents (sevoflurane-CIVIA), 3. TIVA Combined anesthesia with desflurane and intravenous agents (desflurane-CIVIA). Recovery patterns include; extubation time, eye opening time, emergence agitation, postoperative nausia and vomiting and postoperative recovery unit discharge time.
Eligibility
Inclusion Criteria6
- Scheduled for spine surgery
- Expected surgery duration longer than 3 hours
- Use of intraoperative neuromonitoring
- BIS-guided anesthesia administered
- TIVA (with TCI) as the primary anesthetic technique
- Age \>18 years
Exclusion Criteria5
- Emergency surgeries
- Patients receiving sole inhaled anesthesia (no TIVA)
- Perioperative dural injury
- Intraoperative severe hypotension requiring inotropic support
- Hypothermia (based on temperature measured before recovery)
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Interventions
In this group of patients, \<0.5 MAC sevoflurane will be used in combination with TIVA. (TIVA method described above)
In this group of patients, \<0.5 MAC Desflurane will be used in combination with TIVA.
In this group, TIVA will be applied with the combination of BIS-guided propofol + remifentanil.
Locations(1)
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NCT07123870