A Safety, Tolerability, and Efficacy Study of E-islet 01 in Participants With Type 1 Diabetes

This study is testing a new cell therapy called E-islet 01 — a treatment designed to help the body produce insulin again — in people with Type 1 diabetes who struggle with severe low blood sugar episodes. **You may be eligible if...** - You have had Type 1 diabetes for more than 5 years - Your body produces very little or no insulin on its own (confirmed by a special test) - You are on continuous insulin therapy - You have had at least one severe low blood sugar episode in the past year, OR you have hypoglycemia unawareness (you don't feel warning signs when your blood sugar drops) - You are willing and able to check your blood sugar regularly **You may NOT be eligible if...** - You have active infections including tuberculosis, active hepatitis, or HIV - You have had cancer in the past 5 years or are currently on cancer treatment - You have participated in another clinical trial in the past 3 months - You have had an islet cell, organ, or cell therapy transplant in the past year Talk to your doctor to see if this trial is right for you.