RecruitingNCT07127510

Brain NAD in Alzheimer's Disease

Measurement of Brain NAD Levels in Alzheimer's Patients and Control Subjects by 1H-MRS

Sponsor

Florida Atlantic University

Enrollment

20 participants

Start Date

Mar 18, 2026

Study Type

OBSERVATIONAL

Conditions

Alzheimer Disease (AD)

Summary

The goal of this observational study is to learn about the levels of nicotinamide adenine dinucleotide (NAD) in the brains of people with Alzheimer's disease. The study aims to determine if brain NAD levels are lower in people with Alzheimer's disease compared with people of the same age group who do not have Alzheimer's disease. Participants with or without Alzheimer's disease will have a brain imaging session where NAD will be measured using magnetic resonance spectroscopy (MRS). Eight months later, they will have a second, similar, brain imaging session.

Eligibility

Min Age: 65 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is measuring levels of NAD — an important brain energy molecule — in people with Alzheimer's disease using a special type of brain scan, to understand whether low NAD plays a role in the disease. **You may be eligible if...** - You are between 65 and 80 years old - You are able to come to the Florida Atlantic University clinic, speak, and move around independently - You have been diagnosed with Alzheimer's disease by a doctor, confirmed by brain imaging or a blood/spinal fluid test **You may NOT be eligible if...** - You are younger than 65 or older than 80 - Your dementia is so advanced that you would need sedation to undergo an MRI - You are currently receiving Leqembi or Kinsula (IV anti-amyloid treatments) - You have a pacemaker or metal implants that are not MRI-compatible - You have a history of seizures - You work night shifts - You have had cancer in the past 5 years (except superficial skin cancers) - You do not have Alzheimer's and your memory score (MoCA) is below 26 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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