RecruitingNCT07127835

Provocation After Nurse-Directed Assessment (PANDA) Study


Sponsor

The University of Hong Kong

Enrollment

440 participants

Start Date

Sep 1, 2025

Study Type

OBSERVATIONAL

Summary

The study aims to evaluate the effectiveness and safety of a collaborative nurse-allergist approach in penicillin allergy delabeling services. It also seeks to assess the impact on patients' quality of life and compare resource utilization and cost-effectiveness between the nurse-allergist collaborative approach and the traditional allergist-led approach.


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Receiving inpatient or outpatient treatment at a participating hospital during the study period;
  • Possessing a documented penicillin allergy label;
  • Underwent penicillin allergy evaluation by the nurse-allergist collaborative approach or the traditional allergist-led approach
  • Demographic and clinical data required for the study available.

Exclusion Criteria3

  • Patients unable to provide a complete medication history or history of penicillin allergy;
  • Patients with only emergency or short-term treatment records;
  • Patients who have taken steroids, antihistamines, or similar medications within the last 3 days.

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Interventions

DIAGNOSTIC_TESTNurse-led penicillin allergy delabelling service

Patients in this group undergo risk assessment and categorization by nurses to identify low-risk individuals for delabeling. For these patients, nurses will collaborate with allergists in the delabeling process.

DIAGNOSTIC_TESTAllergist-led penicillin allergy delabelling service

Patients assigned to this group will undergo risk assessment and delabeling led by allergists for both low-risk and high-risk cases.


Locations(4)

Prince of Wales Hospital

Hong Kong, Hong Kong

Princess Margaret Hospital

Hong Kong, Hong Kong

Queen Elizabeth Hospital

Hong Kong, Hong Kong

Queen Mary Hospital

Hong Kong, Hong Kong

View Full Details on ClinicalTrials.gov

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NCT07127835