RecruitingPhase 2NCT07130383

A Study of MHB036C Combined With MHB039A in Patients With Advanced Breast Cancer or Other Advanced Malignant Solid Tumors

An Open-label Phase II Clinical Study of MHB036C for Injection Combined With MHB039A for Injection in Patients With Advanced Breast Cancer or Other Advanced Malignant Solid Tumors


Sponsor

Minghui Pharmaceutical (Hangzhou) Ltd

Enrollment

210 participants

Start Date

Sep 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is an open-label, multicenter Phase II study of MHB036C combined with MHB039A in patients with advanced Breast Cancer or other advanced malignant solid tumors. The study was designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of MHB036C and MHB039A combination therapy.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new combination of two investigational drugs — MHB036C and MHB039A — in people with advanced breast cancer or other advanced solid tumors. **You may be eligible if...** - You are between 18 and 75 years old - You have a confirmed diagnosis of a locally advanced or metastatic solid tumor - Your cancer can be measured on imaging scans - Your overall health and organ function are adequate (ECOG score 0–1) - Your life expectancy is at least 3 months - You are willing to use reliable contraception during and for 12 weeks after treatment **You may NOT be eligible if...** - You have had two or more different primary cancers in the past 5 years - You have brain metastases that are not stable - You have received prior treatments that overlap with this study's drugs - You have significant heart, liver, kidney, or lung problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMHB036C for Injection

Intravenous administration

DRUGMHB039A for Injection

Intravenous administration


Locations(1)

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

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NCT07130383


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