Saleh's Technique for Pancreaticojejunostomy (Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate)

This study is testing a new surgical technique (called Saleh's technique) for connecting the remaining pancreas to the small intestine after a major pancreatic surgery called a Whipple procedure. This connection is one of the trickiest parts of the surgery, and the new technique aims to reduce the risk of dangerous leaks afterward. **You may be eligible if...** - You are having a Whipple operation (pancreaticoduodenectomy) to treat a cancerous pancreatic lesion with intent to cure - Your pancreatic tissue is soft and the main pancreatic duct is narrow (less than 3mm) - You are in adequate health to undergo surgery - You have provided written informed consent **You may NOT be eligible if...** - You have a known allergy to cyanoacrylate (a type of surgical glue) or the imaging agent Lipiodol - Your pancreas has an extremely hard or scarred texture - You have significant inflammation of the remaining pancreatic tissue - You have an active infection at the surgical site - You have uncontrolled bleeding problems - Your cancer has already spread to the liver, lymph nodes at a distance, or the lining of the abdomen Talk to your doctor to see if this trial is right for you.