Fluorescence-Guided Optimization of Sarcoma Margins

This study is using a special fluorescent dye visible under a specific light (similar to technology used in detecting cancer margins) to help surgeons better identify and remove all of the tumor tissue during sarcoma surgery. The goal is to reduce the chance of leaving cancer cells behind. **You may be eligible if...** - You are over 18 years old - You have a confirmed intermediate-to-high grade sarcoma (a type of soft tissue or bone cancer) located on a limb or the trunk wall - Your tumor can be surgically removed with intent to cure - You have consented to participate **You may NOT be eligible if...** - You have a history of allergic reactions to iodine-containing substances - You have end-stage kidney disease or very low kidney function (eGFR below 15) - You have decided not to participate or cannot give informed consent - Your tumor is not operable Talk to your doctor to see if this trial is right for you.