RecruitingNot ApplicableNCT07134192

Fluorescence-Guided Optimization of Sarcoma Margins

Sponsor

University of Aarhus

Enrollment

90 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Sarcoma Soft Tissue Sarcoma of the Trunk and Extremities

Summary

This is a Danish national multicenter prospective cohort study to evaluate if fluorescence-guided surgery (FGS) using indocyanine green (ICG) can reduce the rate of positive margins following sarcoma resection.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Biopsy verified intermediate-to-high grade sarcoma of theextremity or trunk wall
Age\>18 years old
Tumor operable
Curative intent at time of surgery
Consent of patient

Exclusion Criteria5

History of allergic reaction to iodine-containing pharmaceuticals
End-stage renal disease or eGFR \<15
Patient decision
Lack of capacity
Inoperability

Interventions

PROCEDUREFluorescent-guided Surgery

Surgical treatment of the patient group will include the administration of a fluorescent dye and intraoperatively the resection will be aided and guided by the fluorescent signal. The wound bed will be inspected, areas with fluorescent signal will be excised and obtained separately for histopathology. Patients will receive the current post-operative standard of care for sarcoma patients