RecruitingNCT07134361

Evaluation by Clinical and Hand Ultrasound in Carpal Tunnel Syndrome

Clinical Analysis and Ultrasound Evaluation of the Median Nerve Cross-sectional Area Before and After Carpal Tunnel Release

Sponsor

University of Sao Paulo General Hospital

Enrollment

106 participants

Start Date

Jun 25, 2025

Study Type

OBSERVATIONAL

Conditions

Carpal Tunnel Syndrome (CTS)Carpal Tunnel Surgery

Summary

Carpal Tunnel Syndrome (CTS) is a common condition where pressure on the median nerve in the wrist causes pain, numbness, and weakness in the hand. Surgery to release the carpal tunnel is often performed to relieve these symptoms. This study will evaluate the changes in the median nerve after surgery and how these changes relate to symptom improvement. Investigators will use ultrasound imaging to measure the nerve size before and at three and six months after surgery. Patients will also complete questionnaires about their symptoms and hand function, and undergo tests to assess strength and sensation. The investigator's goal is to determine whether changes observed on ultrasound are associated with the rate of patient recovery. This may help doctors better monitor healing and improve care for people with CTS.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Clinical diagnosis of primary carpal tunnel syndrome (CTS), confirmed by characteristic symptoms, physical examination findings, and a cross-sectional area superior to 10 mm² in the ultrasonography baseline.
Indication for open carpal tunnel release as part of routine clinical care.

Exclusion Criteria4

Secondary CTS due to inflammatory arthritis, prior wrist trauma, or space-occupying lesions.
History of previous carpal tunnel release in the affected hand.
Concomitant peripheral neuropathies (e.g., diabetic polyneuropathy) or cervical radiculopathy
Inability to undergo ultrasound assessment

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Interventions

PROCEDUREOpen Carpal Tunnel Release

All patients included in the cohort will undergo open carpal tunnel release as part of routine clinical care. The study does not assign the surgical procedure as an investigational intervention; however, it will observe clinical and ultrasonographic outcomes before and after surgery to assess prognostic factors.