Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency

This study is investigating how genetic differences in the immune system affect the response to a pneumococcal (pneumonia) vaccine in people who carry a particular genetic variant called the SERPINA1 Z allele, which is associated with alpha-1 antitrypsin deficiency — a hereditary condition that can cause lung and liver disease. **You may be eligible if...** - You are an adult who carries one copy of the SERPINA1 Z gene variant (heterozygous) - You have either had no COPD flare-ups in the past year, or you have had 2 or more flare-ups - You have not received a pneumococcal conjugate vaccine in the past 5 years, OR you have only received the older polysaccharide-type vaccine **You may NOT be eligible if...** - You have received a pneumococcal conjugate vaccine within the past 5 years - You have a known allergy or severe reaction to pneumococcal conjugate vaccines Talk to your doctor to see if this trial is right for you.