Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity

This study is testing whether semaglutide (a medication already used for weight loss and diabetes) can also help reduce symptoms of depression in people who are overweight or obese and have been diagnosed with major depression. **You may be eligible if...** - You are 18 to 65 years old - You have been diagnosed with major depressive disorder (clinical depression) - Your depression symptoms are moderate to severe (as measured by a standard questionnaire) - Your body mass index (BMI) is 27 or higher (overweight or obese) - You can speak and understand Danish **You may NOT be eligible if...** - You are pregnant, planning to become pregnant in the next 9 months, or breastfeeding - You have a known allergy to GLP-1 medications (like semaglutide, Ozempic, or Wegovy) - You have severe liver, kidney, or heart problems - You have type 1 or type 2 diabetes, or a high blood sugar level - You currently have an active alcohol or drug problem - You are already taking diabetes or weight-loss medication - You are assessed as being at risk for suicide Talk to your doctor to see if this trial is right for you.