18F-choline Positron-emission-tomography - Computed-tomography Compared to Conventional Imaging for Localizing Diseased Parathyroid Glands in Primary Hyperparathyroidism
18F-choline-PET-CT vs Ultrasonography and 99-technetium Sestamibi Scintigraphy in Preoperative Localization for pHPT - A Randomized Trial
Region Skane
88 participants
Jan 1, 2023
INTERVENTIONAL
Conditions
Summary
The goal of this open, single-center, prospective, randomized, clinical study is to compare imaging with \[18F\]fluoromethyl-dimethyl-2-hydroxyethylammonium (18F-choline) positron-emission-tomography - computed-tomography, 18F-ch-PETCT, to conventional imaging with ultrasonography and sestamibi scintigraphy in localizing diseased parathyroid glands in patients diagnosed with primary hyperparathyroidism, pHPT. The question this study aims to answer is: can 18-F-ch-PET-CT more precisely localize diseased parathyroid glands in patients with pHPT before surgery? The objective of the study is to help improve precision in parathyroid surgery, thereby increasing cure rates, minimizing complications, and shortening operation times.
Eligibility
Inclusion Criteria1
- Proven primary hyperparathyroidism Indication for surgery Adult (\>18 years)
Exclusion Criteria1
- Inability to give informed consent Allergy to contrast Pregnancy and breastfeeding
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Interventions
Imaging with 18-F-choline-PET-CT
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07138820