RecruitingNot ApplicableNCT07138820

18F-choline Positron-emission-tomography - Computed-tomography Compared to Conventional Imaging for Localizing Diseased Parathyroid Glands in Primary Hyperparathyroidism

18F-choline-PET-CT vs Ultrasonography and 99-technetium Sestamibi Scintigraphy in Preoperative Localization for pHPT - A Randomized Trial


Sponsor

Region Skane

Enrollment

88 participants

Start Date

Jan 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this open, single-center, prospective, randomized, clinical study is to compare imaging with \[18F\]fluoromethyl-dimethyl-2-hydroxyethylammonium (18F-choline) positron-emission-tomography - computed-tomography, 18F-ch-PETCT, to conventional imaging with ultrasonography and sestamibi scintigraphy in localizing diseased parathyroid glands in patients diagnosed with primary hyperparathyroidism, pHPT. The question this study aims to answer is: can 18-F-ch-PET-CT more precisely localize diseased parathyroid glands in patients with pHPT before surgery? The objective of the study is to help improve precision in parathyroid surgery, thereby increasing cure rates, minimizing complications, and shortening operation times.


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Proven primary hyperparathyroidism Indication for surgery Adult (\>18 years)

Exclusion Criteria1

  • Inability to give informed consent Allergy to contrast Pregnancy and breastfeeding

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Interventions

PROCEDUREParathyroidectomy

Imaging with 18-F-choline-PET-CT


Locations(1)

Skåne University Hospital

Lund, Sweden

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NCT07138820


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