The Effect of Oral Oxytocin and Atosiban on Top-down Attention ( OTAtosiban )
The Influence and Regulatory Role of Exogenous and Endogenous Oxytocin on Top-down Attention in Humans
University of Electronic Science and Technology of China
250 participants
Sep 1, 2025
INTERVENTIONAL
Conditions
Summary
The main aim of the present study is to investigate whether orally (lingual spray) administered oxytocin influences human top-down attention via oxytocin receptors and whether its effects are dose- and task-dependent.
Eligibility
Inclusion Criteria1
- Healthy male subjects without past or current psychiatric or neurological disorders
Exclusion Criteria3
- History of or current neurological/psychiatric disorders;
- Use of psychotropic medications (including nicotine)
- Visual impairments
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Oxytocin (24IU) will be administered as a lingual spray (6, 0.1puffs (4IU per puff) of spray on and under the tongue)
Oxytocin (48IU) will be administered as a lingual spray (6, 0.1ml sprays (8IU per puff) on and under the tongue)
150ug atosiban administered by lingual sprays (6, 0.1ml sprays on and under the tongue)
Placebo administered as a lingual spray (6, 0.1puffs (4IU per puff) of spray on and under the tongue). Placebo has the same composition of 0.9% saline and glycerol as for oxytocin and the atosiban interventions.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07140237