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RecruitingNot ApplicableNCT07142785

Clinical Evaluation of With or Without Internal Limiting Membrane Peeling for Idiopathic Epiretinal Membrane Surgery: A Randomized Controlled Trial

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Enrollment

96 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Idiopathic Epiretinal Membranes

Summary

Idiopathic epiretinal membrane (ERM) is an age-related degenerative retinal condition. One of the primary treatment approaches is vitrectomy combined with epiretinal membrane peeling. However, whether to concurrently perform internal limiting membrane (ILM) peeling remains clinically controversial. Therefore, this study aims to compare the efficacy and safety of performing versus omitting ILM peeling during idiopathic ERM surgery.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Patients aged \>18 years presenting to our hospital within the study period.
  • Patients diagnosed with idiopathic epiretinal membrane (ERM) based on examination.
  • Patients with best-corrected visual acuity (BCVA) ≤ 0.6 or the presence of metamorphopsia.

Exclusion Criteria6

  • Patients with secondary ERM identified during preoperative evaluation (e.g., secondary to retinal vein occlusion).
  • Patients with concomitant ocular diseases affecting the macula, such as macular degeneration, macular schisis, or macular atrophy.
  • Patients with a history of ocular trauma or previous ocular surgery (except for cataract surgery).
  • Patients with severe systemic diseases contraindicated for surgery.
  • Patients with poor compliance or concomitant psychiatric disorders.
  • Patients who participated in other clinical trials during the follow-up period or who were lost to follow-up.
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Interventions

PROCEDUREEpiretinal membrane peeling

All patients will receive standard pars plana vitrectomy, followed by only epiretinal membrane peeling.

PROCEDUREEpiretinal membrane peeling combined with internal limiting membrane peeling

All patients will receive standard pars plana vitrectomy, followed by epiretinal membrane peeling and internal limiting membrane peeling.

Locations(1)

Eye Center of the Second Affiliated Hospital of Zhejiang University

Hangzhou, Zhejiang, China

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NCT07142785