Trial Evaluating the Safety and Efficacy Of MR-Linac-Guided Radiotherapy as Salvage Treatment After External Beam Radiotherapy Recurrence (TUMORNATOR II)

This study is testing a specialized type of radiation treatment that uses a combination of MRI imaging and a radiation delivery machine (MR-Linac) to precisely target a recurrence of prostate cancer in men whose cancer came back after prior external beam radiation therapy. **You may be eligible if...** - You are a man aged 18 or older - You have prostate cancer that came back after prior radiation therapy, confirmed by biopsy - Your testosterone level is adequate (50 ng/dL or higher) - Your prostate size, urinary symptoms, and general health status meet study requirements - Your tumor is visible on MRI - Your cancer has not spread outside the prostate on scans **You may NOT be eligible if...** - You have previously had prostate brachytherapy (internal radiation seeds) - You are currently receiving hormone-blocking therapy - Your cancer has spread outside the prostate or to lymph nodes - You have Crohn's disease or ulcerative colitis - You have a pacemaker, severe claustrophobia, or cannot tolerate an MRI - Your disease-free period after initial radiation was less than 2 years - You have had a TURP (prostate scraping procedure) within the past year Talk to your doctor to see if this trial is right for you.