RecruitingPhase 1NCT07143929

To Observe the CD7-targeted CAR-T Therapy in the Treatment of r/r PTCL

An Open-label, Dose-escalation Early-phase Clinical Study of CD7-targeted CAR-T Cells for the Treatment of Relapsed or Refractory Peripheral T Cell Lymphoma (PTCL)


Sponsor

Peking University People's Hospital

Enrollment

18 participants

Start Date

Aug 18, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

To observe the efficacy and safety of CD7-targeted chimeric antigen receptor T cells in the treatment of refractory or relapsed PTCL.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is examining a new type of immune cell therapy using CAR-T cells that are engineered to target a protein called CD7 found on certain cancers. It is being tested in people with relapsed or refractory peripheral T-cell lymphoma (a type of blood cancer that has not responded to or returned after prior treatments). **You may be eligible if...** - You are between 18 and 80 years old - You have been diagnosed with peripheral T-cell lymphoma confirmed by biopsy - Your lymphoma has relapsed or did not respond to at least one prior treatment - Your tumor tests positive for the CD7 protein - Your heart function and general health status are adequate **You may NOT be eligible if...** - You have primary cutaneous T-cell lymphoma (e.g., mycosis fungoides) or T-lymphoblastic leukemia/lymphoma - You have active cancer in the brain or spinal fluid - You have serious heart conditions including recent heart attack or significant heart rhythm problems - You have active uncontrolled infections, active hepatitis B/C, HIV, or active syphilis - You have autoimmune diseases requiring ongoing treatment - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCAR-T

autologous CD7-targeted CAR-T cells, single injection


Locations(1)

Peking University People's Hospital

Beijing, China

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NCT07143929