RecruitingPhase 3NCT07144163

A Study to Evaluate Atumelnant in Adults With Congenital Adrenal Hyperplasia

A Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Atumelnant in Adult Participants With Classic Congenital Adrenal Hyperplasia (Calm-CAH)

Sponsor

Crinetics Pharmaceuticals Inc.

Enrollment

150 participants

Start Date

Dec 11, 2025

Study Type

INTERVENTIONAL

Conditions

Congenital Adrenal Hyperplasia Classic Congenital Adrenal Hyperplasia

Summary

The purpose of this study is to evaluate the efficacy, safety, PK, and PD of atumelnant in adults with classic CAH due to 21-OHD.

Eligibility

Min Age: 18 YearsMax Age: 74 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Atumelnant and a drug called Placebo for people with classic congenital adrenal hyperplasia and congenital adrenal hyperplasia. The study is currently recruiting participants at 45 locations. People eligible for this study include aged 18 Years to 74 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAtumelnant

Atumelnant, tablets, once daily by mouth

DRUGPlacebo

Placebo, tablets, once daily by mouth

Locations(55)

Crinetics Study Site

Los Angeles, California, United States

Crinetics Study Site

Atlanta, Georgia, United States

Crinetics Study Site

Chicago, Illinois, United States

Crinetics Study Site

Baltimore, Maryland, United States

Crinetics Study Site

Ann Arbor, Michigan, United States

Crinetics Study Site

Minneapolis, Minnesota, United States

Crinetics Study Site

Rochester, Minnesota, United States

Crinetics Study Site

Pittsburgh, Pennsylvania, United States

Crinetics Study Site

Dallas, Texas, United States

Crinetics Study Site

Milwaukee, Wisconsin, United States

Crinetics Study Site

Buenos Aires, Buenos Aires F.D., Argentina

Crinetics Study Site

Buenos Aires, Buenos Aires F.D., Argentina

Crinetics Study Site

CABA, Buenos Aires F.D., Argentina

Crinetics Study Site

CABA, Buenos Aires F.D., Argentina

Crinetics Study Site

Córdoba, Córdoba Province, Argentina

Crinetics Study Site

Herston, Queensland, Australia

Crinetics Study Site

Woolloongabba, Queensland, Australia

Crinetics Study Site

Adelaide, South Australia, Australia

Crinetics Study Site

Parkville, Victoria, Australia

Crinetics Study Site

Nedlands, Western Australia, Australia

Crinetics Study Site

Vienna, Austria

Crinetics Study Site

Fortaleza, Ceará, Brazil

Crinetics Study Site

Curitiba, Paraná, Brazil

Crinetics Study Site

Rio de Janeiro, Rio de Janeiro, Brazil

Crinetics Study Site

Rio de Janeiro, Rio de Janeiro, Brazil

Crinetics Study Site

Porto Alegre, Rio Grande do Sul, Brazil

Crinetics Study Site

Botucatu, São Paulo, Brazil

Crinetics Study Site

São Paulo, São Paulo, Brazil

Crinetics Study Site

São Paulo, São Paulo, Brazil

Crinetics Study Site

Angers, France

Crinetics Study Site

Bron, France

Crinetics Study Site

Nantes, France

Crinetics Study Site

Paris, France

Crinetics Study Site

Pessac, France

Crinetics Study Site

Vandœuvre-lès-Nancy, France

Crinetics Study Site

Munich, Bavaria, Germany

Crinetics Study Site

Würzburg, Germany

Crinetics Study Site

Milan, Milano, Italy

Crinetics Study Site

Milan, Milano, Italy

Crinetics Study Site

Rozzano, Milano, Italy

Crinetics Study Site

Modena, Modena, Italy

Crinetics Study Site

Padova, Padova, Italy

Crinetics Study Site

Palermo, Palermo, Italy

Crinetics Study Site

Naples, Italy

Crinetics Study Site

Roma, Italy

Crinetics Study Site

Leiden, South Holland, Netherlands

Crinetics Study Site

Poznan, Greater Poland Voivodeship, Poland

Crinetics Study Site

Warsaw, Masovian Voivodeship, Poland

Crinetics Study Site

Lodz, Łódź Voivodeship, Poland

Crinetics Study Site

Riyadh, Riyadh Region, Saudi Arabia

Crinetics Study Site

Gothenburg, Sweden

Crinetics Study Site

Stockholm, Sweden

Crinetics Study Site

Cardiff, Wales, United Kingdom

Crinetics Study Site

London, United Kingdom

Crinetics Study Site

Manchester, United Kingdom

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NCT07144163

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