RecruitingPhase 1Phase 2NCT07145047

Clinical Study of Oncolytic Virus in Glioblastoma

Clinical Study on the Application of Oncolytic Virus in Recurrent Glioblastoma

Sponsor

Mianyang Central Hospital

Enrollment

20 participants

Start Date

Nov 2, 2023

Study Type

INTERVENTIONAL

Conditions

Glioblastoma (GBM)

Summary

This clinical trial aims to evaluate whether an oncolytic viral agent can treat recurrent glioblastoma. It will also assess the safety and tolerability of the oncolytic viral agent. The primary question it seeks to answer is: What medical problems do participants experience when injected with the oncolytic viral agent? Researchers will administer the oncolytic viral agent via intratumoral injection to determine its efficacy in treating recurrent glioblastoma. Participant Procedures: Receive the initial injection, followed by additional injections every 2-4 weeks for a total of 6 injections. Undergo physical examinations and tests every 2 to 4 weeks. Record their symptoms, hematological test results, and imaging findings.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an oncolytic virus — a modified virus that is designed to selectively infect and kill cancer cells — injected directly into recurrent glioblastoma (a serious brain tumor that has come back after standard treatment). **You may be eligible if...** - You are between 18 and 70 years old - You have recurrent glioblastoma confirmed by biopsy and visible on MRI (tumor diameter over 1 cm) - Standard treatments are no longer working - You have completed prior radiation, surgery, or chemotherapy at least 28 days before enrollment - Your blood, kidney, and liver function are within normal ranges **You may NOT be eligible if...** - You have cancer that has spread outside the brain (extracranial metastases) - You are currently receiving chemotherapy, immunotherapy, or radiation - You have an active autoimmune disease, active HIV, hepatitis B, or hepatitis C - You are pregnant or breastfeeding - You have a pacemaker or other metal implants that prevent MRI - You have a history of encephalitis, multiple sclerosis, or other serious brain infections or diseases - You have been vaccinated within the past 30 days - You have previously received oncolytic virus therapy or gene therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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